Synthesis and biological evaluation of prodrugs of zidovudine

DOI: 10.1021/jm00167a034

Source and publish data:

Journal of Medicinal Chemistry p. 1505 - 1510 (1990)

Update date:2022-08-04

Topics: Synthesis Biological Evaluation Prodrugs

Authors:

Aggarwal

Gogu Gogu

Rangan Rangan

Agrawal Agrawal

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Article abstract of DOI:10.1021/jm00167a034

A series of prodrugs of zidovudine (AZT) has been synthesized in an effort to enhance the uptake of the prodrugs by the HIV-1 infected cells and to increase the plasma half-life of AZT. The 5'-OH function of AZT was esterified with various acids in the pr

Full text of DOI:10.1021/jm00167a034

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