The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3 S,4 S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)

DOI: 10.1021/acs.jmedchem.5b00300

Source and publish data:

Journal of Medicinal Chemistry p. 4291 - 4308 (2015)

Update date:2022-08-15

Topics:

Authors:

Shaffer, Christopher L.

Patel, Nandini C.

Schwarz, Jacob

Scialis, Renato J.

Wei, Yunjing

Hou, Xinjun J.

Xie, Longfei

Karki, Kapil

Bryce, Dianne K.

Osgood, Sarah M.

Hoffmann, William E.

Lazzaro, John T.

Chang, Cheng

McGinnis, Dina F.

Lotarski, Susan M.

Liu, Jianhua

Obach, R. Scott

Weber, Mark L.

Chen, Laigao

Zasadny, Kenneth R.

Seymour, Patricia A.

Schmidt, Christopher J.

Hajós, Mihály

Hurst, Raymond S.

Pandit, Jayvardhan

O'Donnell, Christopher J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/acs.jmedchem.5b00300

A unique tetrahydrofuran ether class of highly potent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor potentiators has been identified using rational and structure-based drug design. An acyclic lead compound, containing an ether-linked isopr

Full text of DOI:10.1021/acs.jmedchem.5b00300

Products guided by the article

Product name:N-{(3S,4S)-4-[(2'-cyanobiphenyl-4-yl)oxy]tetrahydrofuran-3-yl}propane-2-sulfonamide

Cas No:1258963-58-4

R&D Labs maybe for 1258963-58-4

HuiFeiChem PharmaTech Co.Ltd

Contact:0510-85393305

Address:1619 Huishan Avenue, Huishan District, Wuxi,
Nanjing Duly Biotech Co., Ltd

website:http://www.dulynet.com/

Contact:025-84699383 -8003

Address:Room 503, Building 2, Chuangxinhui, No. 61 Wenjing Road, High-tech Development Zone, Pukou District, Nanjing City, Jiangsu Province Nanjing, Jiangsu
Changsha Yonta Industry Co., Ltd.

Contact:+ 86-731-8535 2228

Address:Rm.1717, North Bldg., No.368, East 2nd Ring Road(2nd Section)
Fuxin Jintelai Fluorin Chemical Co., Ltd.

Contact:+86-0418-8229599

Address:, 7th Huagong Road, Fluorine industry development zone (Yimatu Town,Fumeng County),Fuxin City, Liaoning Province, China
Hebei Think-Do Environment Co., Ltd

website:http://www.thinkdo-environment.com

Contact:0311-86510809-

Address:No 6, Shilian Middle Street, Circular Chemical Industry Park

Relevant to this article

A value-added use of volatile turpentine: antifungal activity and QSAR study of β-pinene derivatives against three agricultural fungi

Doi:10.1039/c5ra10660e
(2015)
First general route to substituted α-arylamino-α′ chloropropan-2-ones by oxidation of N-protected aminohalohydrins: The importance of disrupting hydrogen bond networks

Doi:10.1055/s-0030-1257938
(2010)
1,1-Difluoroethen-Nickel-Ligand-Komplexe

Doi:10.1016/0022-328X(89)85070-3
(1989)
Highly regio- and chemoselective palladium(0)-mediated allylic substitution of difunctional allylic halides with phenols

Doi:10.1016/j.tetlet.2010.09.125
(2010)
A comparative study on Suzuki-type ¹¹C-methylation of aromatic organoboranes performed in two reaction media

Doi:10.1002/jlcr.3932
(2021)
Cleavage of Aldehyde Hydrazonium Iodides under Mild Conditions. A Convenient Route to Chiral Nitriles of High Enantiomeric Purity

Doi:10.1021/jo00297a072
(1990)

Article Doi