Bioorganic and Medicinal Chemistry Letters p. 7444 - 7449 (2010)
Update date:2022-08-06
Topics:
Beaulieu, Christian
Isabel, Elise
Fortier, Angélique
Massé, Frédéric
Mellon, Christophe
Méthot, Nathalie
Ndao, Momar
Nicoll-Griffith, Deborah
Lee, Doris
Park, Hyeram
Black, W. Cameron
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease is described. The identified inhibitors bearing an amino nitrile warhead in P1 exhibit low nanomolar in vitro potency against cruzipain. Further SAR in P2 por
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