Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

DOI: 10.1016/j.ejmech.2010.09.060

Source and publish data:

European Journal of Medicinal Chemistry p. 5943 - 5949 (2010)

Update date:2022-08-03

Topics:

Authors:

Hu, Lei Hu, Lei

Lan, Ping

Song, Qiu-Ling

Huang, Zhi-Jian

Sun, Ping-Hua

Zhuo, Chao

Wang, Ying

Xiao, Shunian

Chen, Wei-Min

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Article abstract of DOI:10.1016/j.ejmech.2010.09.060

A series of C-12 pyrazolinyl spiro ketolide derivatives were designed and synthesized. The C-12 modifications involved replacing the natural C-12 methyl group in clarithromycin core with different pyrazolinyl spiros via chemical synthesis. Potential anti-

Full text of DOI:10.1016/j.ejmech.2010.09.060

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