One-Pot Synthesis of N-(2-Heteroaryl)-α-amino Esters by the Regiospecific 2-N-(α-Alcoxycarbonyl)alkylation of 2-Aminoazines and -azoles with Glyoxals and Alcohols Promoted by Perchloric Acid

DOI: 10.1021/jo00297a033

Source and publish data:

Journal of Organic Chemistry p. 3143 - 3147 (1990)

Update date:2022-07-31

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Authors:

Alcaide, Benito

Plumet, Joaquin

Sierra, Miguel A.

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Article abstract of DOI:10.1021/jo00297a033

2-Amino heterocycles, including pyridine, diazine, and azole derivatives, are readily converted into N-(2-heteroaryl)-α-amino esters 4 in a one-pot sequence by reaction with glyoxals and alcohols in the presence of perchloric acid.In addition, the corresp

Full text of DOI:10.1021/jo00297a033

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