One-Pot Synthesis of N-(2-Heteroaryl)-α-amino Esters by the Regiospecific 2-N-(α-Alcoxycarbonyl)alkylation of 2-Aminoazines and -azoles with Glyoxals and Alcohols Promoted by Perchloric Acid

DOI: 10.1021/jo00297a033

Source and publish data:

Journal of Organic Chemistry p. 3143 - 3147 (1990)

Update date:2022-07-31

Topics:

Authors:

Alcaide, Benito

Plumet, Joaquin

Sierra, Miguel A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00297a033

2-Amino heterocycles, including pyridine, diazine, and azole derivatives, are readily converted into N-(2-heteroaryl)-α-amino esters 4 in a one-pot sequence by reaction with glyoxals and alcohols in the presence of perchloric acid.In addition, the corresp

Full text of DOI:10.1021/jo00297a033

Products guided by the article

Product name:isopropyl N-(2-pyridyl)phenylglycinate

Cas No:126190-23-6

R&D Labs maybe for 126190-23-6

Quzhou Ruiyuan chemical Co., Ltd

Contact:+86-570-3039321/3039361/3039308

Address:18# Huayang Road,Quzhou High-tech Industrial Park, Zhejiang China.
Shanghai Zhihua ChemTech Co., Ltd.

Contact:+86-13774313779

Address:Room 817 Suite B 3333 Shenjiang Road
Shandong LuZhou Amino Acid Co., Ltd

Contact:86-539-2218025

Address:yishui economic and technical development zone zhenxing south road
Jiangsu Dacheng Pharmaceutical and Chemical Co.,Ltd

Contact:+86-0517-87036900

Address:Chuzhou Chemical park, Huai'an, Jiangsu Province
Simagchem Corporation

website:http://www.simagchem.com

Contact:+86-592-2680277

Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China

Relevant to this article

An efficient formal synthesis of (S)-dapoxetine from enantiopure 3-hydroxy azetidin-2-one

Doi:10.1016/j.tet.2008.11.042
(2009)
L-type calcium channel blockers: From diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives

Doi:10.1021/jm801351u
(2009)
Regioselective syntheses of 2- and 4-formylpyrido[2,1-b]benzoxazoles

Doi:10.1021/jo900267c
(2009)
Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities

Doi:10.1021/acs.jmedchem.0c00996
(2020)
A 3₁₀-helix single turn enforced by crosslinking of lysines with 1,1′-ferrocenedicarboxylic acid

Doi:10.1016/j.jorganchem.2008.11.055
(2009)
Design and synthesis of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity

Doi:10.1016/j.ejmech.2008.07.010
(2009)

Article Doi