One-Pot Synthesis of N-(2-Heteroaryl)-α-amino Esters by the Regiospecific 2-N-(α-Alcoxycarbonyl)alkylation of 2-Aminoazines and -azoles with Glyoxals and Alcohols Promoted by Perchloric Acid

DOI: 10.1021/jo00297a033

Source and publish data:

Journal of Organic Chemistry p. 3143 - 3147 (1990)

Update date:2022-07-31

Topics:

Authors:

Alcaide, Benito

Plumet, Joaquin

Sierra, Miguel A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00297a033

2-Amino heterocycles, including pyridine, diazine, and azole derivatives, are readily converted into N-(2-heteroaryl)-α-amino esters 4 in a one-pot sequence by reaction with glyoxals and alcohols in the presence of perchloric acid.In addition, the corresp

Full text of DOI:10.1021/jo00297a033

Products guided by the article

Product name:isopropyl N-(2-pyridyl)phenylglycinate

Cas No:126190-23-6

R&D Labs maybe for 126190-23-6

Yuan Shi(SuQian)Biotechnology Co.,Ltd

website:http://www.yuanshibio.com

Contact:+86-527-84226672

Address:jiangsu suqian
LIANYUNGANG YC FINE CHEMICAL CO., LTD

Contact:+86-518-858 99188

Address:Shangdong Modern Bldg, South Greenpark Road, Lianyungang, Jiangsu Pro. China
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan
Jiaxing Trustworthy Import And Export Co.,Ltd

Contact:+86-573-82030555

Address:Room 1202, Unit B, Charming plaza,No.1558 East Zhongshan Road , Jiaxing City, Zhejiang Province, China.
CHENGDU CHENLV HERB CO.,LTD

Contact:+86-28-88523492

Address:714rooms of Time Square, Pujiang County

Relevant to this article

An efficient formal synthesis of (S)-dapoxetine from enantiopure 3-hydroxy azetidin-2-one

Doi:10.1016/j.tet.2008.11.042
(2009)
L-type calcium channel blockers: From diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives

Doi:10.1021/jm801351u
(2009)
Regioselective syntheses of 2- and 4-formylpyrido[2,1-b]benzoxazoles

Doi:10.1021/jo900267c
(2009)
Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities

Doi:10.1021/acs.jmedchem.0c00996
(2020)
A 3₁₀-helix single turn enforced by crosslinking of lysines with 1,1′-ferrocenedicarboxylic acid

Doi:10.1016/j.jorganchem.2008.11.055
(2009)
Design and synthesis of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity

Doi:10.1016/j.ejmech.2008.07.010
(2009)

Article Doi