Acyclic analogs of kainoids: Their syntheses and depolarizing activities

Article abstract of DOI:10.1016/0040-4020(95)01058-0

Four stereoisomers of the β-benzylglutamic acids were synthesized by the Michael addition of benzylphenylsulfide to protected (4S)- and (4R)-4-amino-2-penten-5-olide and to protected (2S)- and (2R)-3-dehydro-2-hydroxymethyl-5-pyrrolidone. The β-methallyl- and β-isobutylglutamic acids were also synthesized in a similar manner. The depolarizing activities of these synthesized compounds were observed.