Tetrahedron Letters p. 4025 - 4028 (1997)
Update date:2022-08-04
Topics:
Chen, Wei-Chuan
Vera, Matthew D.
Joullie, Madeleine M.
Magnesium bromide etherate has been previously shown to cleave β-(trimethylsilyl)ethoxymethyl (SEM) esters of aliphatic acids. This methodology has now been extended to amino acid and peptide derivatives in the presence of protecting groups typically encountered in peptide chemistry, including the Boc, Cbz, Fmoc and Troc carbamates as well as benzyl-, tert-butyl- and tert-butyldimethylsilyl ethers. The stability of fluoride sensitive protecting groups to magnesium bromide allows for added selectivity in the removal of SEM esters in organic synthesis.
View MoreShanghai birch chemical technology co.,ltd
Contact:+86-21-54096810
Address:No.2588,Jungong Road,Shanghai,China
Contact:+86-021-58123769
Address:No.780 of Cailun Road,Zhangjiang Hi-tech Park,Pudong,Shanghai
Huangshi Shennong Chemical Technology Co., Ltd
Contact:+86-714-3072290
Address:Eastern industrial park , Tieshan district , Huangshi city ,Hubei province , China
Shangyu Sanhechemicals Co.,LTD.
Contact:86-0571-56696839
Address:Num.2952,Nanhuan Road,Binjiang District,Hangzhou,China
Contact:86-371-63655023
Address:No.85,jinshui road,zhengzhou,China
Doi:10.1007/BF00956961
(1989)Doi:10.1007/s11164-010-0211-9
(2010)Doi:10.1016/j.ejmech.2013.08.011
(2013)Doi:10.1080/00397919208021136
(1992)Doi:10.1016/0040-4020(67)85041-5
(1967)Doi:10.1021/ja973605c
(1998)
