Preparation of N-1 substituted thieno[3,4-d]pyrimidine-2,4-diones

Article abstract of DOI:10.1080/00397919208021136

The preparation of N-1 substituted thieno[3,4-d]pyrimidine-2,4-diones is presented. The key feature of this synthesis is the use of a 2,4-dimethoxybenzyl protecting group at N-3 that was readily removed in methanesulfonic acid.

Full text of DOI:10.1080/00397919208021136

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Preparation of N-1 Substituted
Thieno[3,4-d]pyrimidine-2,4-
diones
Ronald K. Russell a , Caroline E. van Nievelt a
Richard A. Rampulla a & Dieter H. Klaubert a
a The R. W. Johnson Pharmaceutical Research
,
Institute, Division of Medicinal Chemistry , P. O. Box
300, Route 202, Raritan, N. J., 08869-0602
Published online: 23 Sep 2006.
To cite this article: Ronald K. Russell , Caroline E. van Nievelt , Richard A.
Rampulla & Dieter H. Klaubert (1992) Preparation of N-1 Substituted Thieno[3,4-
d]pyrimidine-2,4-diones, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 22:22, 3221-3227, DOI:
10.1080/00397919208021136
To link to this article: http://dx.doi.org/10.1080/00397919208021136
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