Catalytic asymmetric aza-Michael-Michael addition cascade: Enantioselective synthesis of polysubstituted 4-aminobenzopyrans

DOI: 10.1021/ol1031188

Source and publish data:

Organic Letters p. 808 - 811 (2011)

Update date:2022-08-05

Topics:

Authors:

Wang, Xu-Fan

An, Jing

Zhang, Xiao-Xiao

Tan, Fen

Chen, Jia-Rong

Xiao, Wen-Jing

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Article abstract of DOI:10.1021/ol1031188

A catalytic asymmetric aza-Michael-Michael addition cascade of anilines to nitroolefin enoates in the presence of chiral bifunctional thiourea catalysts has been disclosed. This reaction provides a mild and efficient approach to polysubstituted chiral 4-a

Full text of DOI:10.1021/ol1031188

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Product name:ethyl 2-((2S,3R,4S)-4-((2-hydroxy-3-methylphenyl)amino)-3-methyl-3-nitrochroman-2-yl)acetate

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