Facile ring-opening of azabicyclic [3.1.0]-and [4.1.0]aminocyclopropanes to afford 3-piperidinone and 3-azepinone

Article abstract of DOI:10.1021/ol103105q

Azabicyclic [3.1.0] and [4.1.0] Kulinkovich products underwent a facile reduction/fragmentation to afford a variety of 3-piperidinones and 3-azepinones, respectively, in the presence of catalytic palladium on carbon and formic acid in an atmosphere of hyd