Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of spirocyclic piperidines

Article abstract of DOI:10.1016/j.bmcl.2011.10.013

The discovery and SAR of a novel series of spirocyclic renin inhibitors are described herein. It was found that by restricting the northern aromatic plate to the bioactive conformation through spirocyclization, increase in renin potency and decrease in hE