APPLICATION OF ORGANOLITHIUM AND RELATED REAGENTS IN SYNTHESIS. PART 7. SYNTHESIS AND METALLATION OF 4-METHOXYPICOLIN- AND 2-METHOXYISONICOTIN-ANILIDES. A USEFUL METHOD FOR PREPARATION OF 2,3,4-TRISUBSTITUTED PYRIDINES

DOI: 10.1016/S0040-4020(01)89209-7

Source and publish data:

Tetrahedron p. 7469 - 7476 (1989)

Update date:2022-09-26

Topics:

Authors:

Epsztajn, Jan

Bieniek, Adam

Plotka, Mieczyslaw W.

Suwald, Krzysztof

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Article abstract of DOI:10.1016/S0040-4020(01)89209-7

The synthesis and metallation of 4-methoxypicolin- and 2-methoxyisonicotin-anilides as a way of regiospecific transformation of picolinic and isonicotinic acids into 2,3,4-trisubstituted pyridines, is described.The resulted C-alkylated derivatives underwent smooth acid - catalysed conversion into the corresponding pyridones.

Full text of DOI:10.1016/S0040-4020(01)89209-7

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