APPLICATION OF ORGANOLITHIUM AND RELATED REAGENTS IN SYNTHESIS. PART 7. SYNTHESIS AND METALLATION OF 4-METHOXYPICOLIN- AND 2-METHOXYISONICOTIN-ANILIDES. A USEFUL METHOD FOR PREPARATION OF 2,3,4-TRISUBSTITUTED PYRIDINES

DOI: 10.1016/S0040-4020(01)89209-7

Source and publish data:

Tetrahedron p. 7469 - 7476 (1989)

Update date:2022-09-26

Topics:

Authors:

Epsztajn, Jan

Bieniek, Adam

Plotka, Mieczyslaw W.

Suwald, Krzysztof

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(01)89209-7

The synthesis and metallation of 4-methoxypicolin- and 2-methoxyisonicotin-anilides as a way of regiospecific transformation of picolinic and isonicotinic acids into 2,3,4-trisubstituted pyridines, is described.The resulted C-alkylated derivatives underwent smooth acid - catalysed conversion into the corresponding pyridones.

Full text of DOI:10.1016/S0040-4020(01)89209-7

Products guided by the article

Product name:4-Pyridinecarboxamide, 2-methoxy-N,3-dimethyl-N-phenyl-

Cas No:126798-24-1

R&D Labs maybe for 126798-24-1

Jiangsu Institute of Ecomones Co., Ltd

website:http://www.jsmone.com

Contact:+86-519-82821700

Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
Taimai Sanluck Pharmaceutical Co.,Ltd

Contact:86-592-7662921

Address:8D,No.186,Huarong Road,Huli,Xiamen,China
Geen Chemical Technology Co., Ltd

Contact:86-769-21660847

Address:1408, Yingfeng Commercial Center, Nancheng District
Antimex Chemical Limied

website:http://www.antimex.com

Contact:0086-21-50563169

Address:Room1027,No.Jinyu Road,Pudong
Jiangxi Dongxu Chemical Science & Technology Co.,Ltd

Contact:+86-791-86899381

Address:Nanchang, Jiangxi, China

Relevant to this article

Harnessing hypervalent iodonium ylides as carbene precursors: C-H activation of: N -methoxybenzamides with a Rh(iii)-catalyst

Doi:10.1039/d0cc06038k
(2020)
Synthesis and pharmacological profile of a new selective G protein-coupled receptor 119 agonist; 6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl) piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one

Doi:10.1248/cpb.c12-00484
(2012)
Structural fine-tuning of a multifunctional cytochrome P450 monooxygenase

Doi:10.1021/ja110146z
(2011)
Optimized TrkB Agonist Ameliorates Alzheimer's Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase

Doi:10.1021/acschemneuro.1c00181
(2021)
Anti-inflammatory, analgesic, anticonvulsant and antiparkinsonian activities of some pyridine derivatives using 2,6-disubstituted isonicotinic acid hydrazides

Doi:10.1002/ardp.201000088
(2010)
Copper-catalyzed oxidative cross-coupling of N,N-Dimethylanilines with heteroarenes under molecular oxygen

Doi:10.1021/jo1023975
(2011)

Article Doi