APPLICATION OF ORGANOLITHIUM AND RELATED REAGENTS IN SYNTHESIS. PART 7. SYNTHESIS AND METALLATION OF 4-METHOXYPICOLIN- AND 2-METHOXYISONICOTIN-ANILIDES. A USEFUL METHOD FOR PREPARATION OF 2,3,4-TRISUBSTITUTED PYRIDINES

DOI: 10.1016/S0040-4020(01)89209-7

Source and publish data:

Tetrahedron p. 7469 - 7476 (1989)

Update date:2022-09-26

Topics:

Authors:

Epsztajn, Jan

Bieniek, Adam

Plotka, Mieczyslaw W.

Suwald, Krzysztof

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(01)89209-7

The synthesis and metallation of 4-methoxypicolin- and 2-methoxyisonicotin-anilides as a way of regiospecific transformation of picolinic and isonicotinic acids into 2,3,4-trisubstituted pyridines, is described.The resulted C-alkylated derivatives underwent smooth acid - catalysed conversion into the corresponding pyridones.

Full text of DOI:10.1016/S0040-4020(01)89209-7

Products guided by the article

Product name:4-Pyridinecarboxamide, 2-methoxy-N,3-dimethyl-N-phenyl-

Cas No:126798-24-1

R&D Labs maybe for 126798-24-1

changsha chenjin chemical technology co.,LtD(expird)

Contact:86-731-84451263

Address:Room 201/217-218, 101 Jingyuan Electronic Technology Co.,Ltd. Testing Center, No.69, Lufeng Road, High-tech Development Zone, Changsha, China
Shanghai Dianyang Industry Co.,ltd

Contact:+86 21 6492 4669

Address:Chejing RD, Songjiang District, Shanghai, China
Hubei Lingsheng Pharmaceuticals Co., Ltd.

Contact:+86-0710-3538058

Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
X.T.Y Environ-Tech Co.,Ltd

Contact:+86-310-7092106

Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
qingdao goldenchem imp and exp co.,ltd.

Contact:532-55579246

Address:no.62 ,haier road laoshan distirct

Relevant to this article

Harnessing hypervalent iodonium ylides as carbene precursors: C-H activation of: N -methoxybenzamides with a Rh(iii)-catalyst

Doi:10.1039/d0cc06038k
(2020)
Synthesis and pharmacological profile of a new selective G protein-coupled receptor 119 agonist; 6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl) piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one

Doi:10.1248/cpb.c12-00484
(2012)
Structural fine-tuning of a multifunctional cytochrome P450 monooxygenase

Doi:10.1021/ja110146z
(2011)
Optimized TrkB Agonist Ameliorates Alzheimer's Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase

Doi:10.1021/acschemneuro.1c00181
(2021)
Anti-inflammatory, analgesic, anticonvulsant and antiparkinsonian activities of some pyridine derivatives using 2,6-disubstituted isonicotinic acid hydrazides

Doi:10.1002/ardp.201000088
(2010)
Copper-catalyzed oxidative cross-coupling of N,N-Dimethylanilines with heteroarenes under molecular oxygen

Doi:10.1021/jo1023975
(2011)

Article Doi