Tetrahedron p. 7469 - 7476 (1989)
Update date:2022-09-26
Topics:
Epsztajn, Jan
Bieniek, Adam
Plotka, Mieczyslaw W.
Suwald, Krzysztof
The synthesis and metallation of 4-methoxypicolin- and 2-methoxyisonicotin-anilides as a way of regiospecific transformation of picolinic and isonicotinic acids into 2,3,4-trisubstituted pyridines, is described.The resulted C-alkylated derivatives underwent smooth acid - catalysed conversion into the corresponding pyridones.
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