Synthesis and Biological Activities of Novel 5-(2-Acylethynyl)uracils

DOI: 10.1021/jm00169a026

Source and publish data:

Journal of Medicinal Chemistry p. 1975 - 1979 (1990)

Update date:2022-09-26

Topics:

Authors:

Kundu, Nitya G.

Das, Biswajit

Spears, C. Paul

Majumdar, Anjali

Kang, Sang-Ihn

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Article abstract of DOI:10.1021/jm00169a026

5-(2-Acylethynyl)-2,4-dimethoxypyrimidines (3-6) were synthesized in excellent yields from 2,4-dimethoxy-5-<2-(trimethylsilyl)ethynyl>pyrimidine (2) by treatment with acid chlorides in the presence of anhydrous aluminum chloride.Compounds 3-6 were deblock

Full text of DOI:10.1021/jm00169a026

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