Research on Chemical Intermediates p. 3105 - 3110 (2013)
Update date:2022-07-31
Topics:
Gu, Ning
Yang, Jiabin
Wang, Peng
Li, Lushen
Chen, Yang
Ji, Min
The Wittig-Horner reaction is a classic method to get alkenes by reaction phosphonates with carbonyl compounds. In this study, it was used for the synthesis of the anticancer drug neratinib. In this method, ethyl diethoxyphosphinylacetate and dimethylaminoacetaldehyde diethylacetal, replacing (E)-4-(dimethylamino)but-2-enoyl acid hydrochloride and oxalyl chloride, were used to synthesize the 6-position side chain of neratinib.
View MoreContact:+86-633-8332928
Address:No.1,Huanghai Yilu.Rizhao,Shandong
Anhui Eapearl Chemical Co., Ltd.
Contact:86-562-5858458
Address:358 South Huaihe Road
Shanghai Kefu Chemical Co.,Ltd.
Contact:+86-21-34616196
Address:Room601-602, Xuhui Business Building, No.168, Yude Road, Shanghai
Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd
website:http://www.tianpharm.com
Contact:86-755-23284190
Address:B302,2 unit, Jin Lian Building, No. 134 Qianjin 2 Road, Taoyuan village, Xixiang Street, Baoan,Shenzhen,China
Tianjin Anda North Industrial & Business Co.Ltd.
Contact:86-22-24999306
Address:No.11 Erwei Road,Dongli Development Area,Tianjin,China
Doi:10.1002/ejoc.201001502
(2011)Doi:10.1002/ejoc.201001455
(2011)Doi:10.1002/chem.201003015
(2011)Doi:10.1039/b927347f
(2010)Doi:10.1039/c8cc07269h
(2018)Doi:10.1016/S0040-4039(02)00989-9
(2002)