Enzymatic preparation of isomerically pure 1,4:3,6-dianhydro-D-glucitol monoacetates - Precursors for isoglucitol 2- and 5-mononitrates

Article abstract of DOI:10.1016/S0957-4166(00)82092-3

Using a highly selective lipase from Pseudomonas sp. (SAM II) the isomerically pure title compounds 3 and 4 were prepared either by enzymatic hydrolysis (alcoholysis) of the diacetate 2 or by enzymatic esterification of the diol 1, respectively. They were further converted into the pharmaceutically important, isomerically pure 1,4:3,6-dianhydro-D-glucitol-2- and 5-nitrates 6 and 7.