Design and Synthesis of Highly Potent and Selective Cyclic Dynorphin A Analogues

DOI: 10.1021/jm00169a007

Source and publish data:

Journal of Medicinal Chemistry p. 1874 - 1879 (1990)

Update date:2022-08-04

Topics:

Authors:

Kawasaki, Andrew M.

Knapp, Richard J.

Kramer, Thomas H.

Wire, William S.

Vasquez, Olga S.

et al. et al.

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Article abstract of DOI:10.1021/jm00169a007

We have designed and synthesized several cyclic disulfide-containing peptide analogues of dynorphin A (Dyn A) which are conformationally constrained in the putative "address" segment of the opioid ligand.Several of these Dyn A analogues exhibit unexpected

Full text of DOI:10.1021/jm00169a007

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