Journal of the Chemical Society. Chemical communications p. 1769 - 1770 (1989)
Update date:2022-08-05
Topics:
Raju, Natarajan
Robins, Roland K.
Vaghefi, Morteza M.
Condensation of 2-bromo-6-(4-nitrophenylethoxy)purine as the trimethylsilyl derivative (5a) with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose, 1-O-acetyl-2,3-di-O-benzoyl-5-deoxy-5-diethoxy-phosphinyl-β-D-ribofuranose, and (2-acetoxyethoxy)methyl bromide resulted in N9-regioselective alkylation to give (6a-c), which were then converted to guanine and hypoxanthine nucleosides, nucleotides, and Acyclovir analogues, respectively.
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Doi:10.1002/chir.22429
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(1973)
