An efficient synthesis of 3-substituted 3H-isobenzofuran-1-ylidenamines by the reaction of 2-cyanobenzaldehydes with organolithiums and their conversion into isobenzofuran-1(3h)-ones

Article abstract of DOI:10.3987/COM-10-12071

A new and efficient synthesis of 3-substituted 3H-isobenzofuran-1- ylidenamines by the reaction of 2-cyanobenzaldehydes with nucleophiles, such as organolithiums or lithium enolates of t-butyl acetate and N,Ndimethylacetamide, is reported. Some of these products were converted into the corresponding 3-substituted isobenzofuran-1(3H)-ones (phthalides) upon treatment with hydrochloric acid in satisfactory yields. The Japan Institute of Heterocyclic Chemistry.

Full text of DOI:10.3987/COM-10-12071

HETEROCYCLES, Vol. 83, No. 1, 2011
99
HETEROCYCLES, Vol. 83, No. 1, 2011, pp. 99 - 106. © The Japan Institute of Heterocyclic Chemistry
Received, 28th September, 2010, Accepted, 24th November, 2010, Published online, 2nd December, 2010
DOI: 10.3987/COM-10-12071
AN
EFFICIENT
SYNTHESIS
OF
3-SUBSTITUTED
3H-ISOBENZOFURAN-1-YLIDENAMINES BY THE REACTION OF
2-CYANOBENZALDEHYDES WITH ORGANOLITHIUMS AND THEIR
CONVERSION INTO ISOBENZOFURAN-1(3H)-ONES
Kazuhiro Kobayashi,* Kota Matsumoto, and Hisatoshi Konishi
Division of Applied Chemistry, Department of Chemistry and Biotechnology,
Graduate School of Engineering, Tottori University, 4-101 Koyama-minami,
Tottori 680-8552, Japan; E-mail: kkoba@chem.tottori-u.ac.jp
Abstract – A new and efficient synthesis of 3-substituted 3H-isobenzofuran-
1-ylidenamines by the reaction of 2-cyanobenzaldehydes with nucleophiles, such
as organolithiums or lithium enolates of t-butyl acetate and N,N-
dimethylacetamide, is reported. Some of these products were converted into the
corresponding 3-substituted isobenzofuran-1(3H)-ones (phthalides) upon
treatment with hydrochloric acid in satisfactory yields.
There have been only a few reports on the preparation of 3H-isobenzofuran-1-ylidenamine derivatives in
the literature. The synthesis of 3,3-disubstituted derivatives by the reaction of 2-lithiobenzonitrile with
ketones has been reported by Parham and Jones in 1976.1 In 1984 Kovtunenko and coworkers reported
the synthesis of 3-phenyl-3H-isobenzofuran-1-ylidenamine by the hydride reduction of
2-benzoylbenzonitrile.2 Van der Eycken and coworkers also reported the synthesis of 3-nonsubstituted
3H-isobenzofuran-1-ylidenamines by the hydride reduction of 2-cyanobenzaldehydes.3 Recently,
formation of this skeleton in the reaction of 1-isocyano-2-lithiobenzene with aldehydes as special cases
has been reported by Alexander and de Meijere.4 We report here an efficient one-pot method to
synthesize 3-substituted 3H-isobenzofuran-1-ylidenamines by the reaction of 2-cyanobenzaldehydes with
nucleophiles, such as organolithiums or lithium enolates of t-butyl acetate and N,N-dimethylacetamide.
The conversion of some of these 3H-isobenzofuran-1-ylidenamines into the corresponding 3-substituted
phthalides by acid hydrolysis is also reported. The biological activities5 of phthalide derivatives have
attracted the attention of many synthetic chemists.6
The synthesis of 3-alkyl(or aryl)-3H-isobenzofuran-1-ylidenamines (2) from 2-cyanobenzaldehydes (1)
and organolithiums is outlined in Scheme 1. Thus, treatment of 1 with organolithiums was conducted in

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HETEROCYCLES, Vol. 83, No. 1, 2011
THF to give 2. An organolithium adds to the carbonyl carbon of 1 to generate a lithium alkoxide
intermediate, which then attacks intramolecularly on the cyano carbon to yield lithium
3H-isobenzofuran-1-ylidenamide intermediate. This addition/ring closure sequence between
2-cyanobenzaldehydes (1a, b) and organolithiums proceeded smoothly at –78 ˚C to give, after usual
workup and subsequent purification by column chromatography on silica gel, the desired
3H-isobenzofuran-1-ylidenamines (2a-e) in generally moderate-to-fair yields, as can be seen from Table 1,
Entries 1-5. 2-Cyano-5-methoxybenzaldehyde (1c) was first treated with 4-methoxyphenyllithium under
the same conditions as described above, but only a small amount of the corresponding
3H-isobenzofuran-1-ylidenamine (2f) was detected along with
a
considerable amount of
1
2-[hydroxy(4-methoxyphenyl)methyl]benzonitrile by H NMR analyses of the mixture after aqueous
workup. This is most likely due to the lower reactivity of the nitrile function in compound 1c. TLC
monitoring of the reaction also revealed that while the addition of 4-methoxyphenyl anion to the carbonyl
function proceeded immediately at this temperature, ring closure by the addition of the resulting alkoxide
to the cyano function was very sluggish. The production of 2f in a somewhat lower yield compared to
those of 2a-e, however, was achieved by raising the reaction temperature to 0 ˚C (Entry 6). Attempts to
obtain the respective 3H-isobenzofuran-1-ylidenamines from 2-cyano-4,5-methylenedioxybenzaldehyde
and organolithiums resulted in an almost quantitative recovery of the starting materials. Presumably this
result indicates that the methylenedioxy substituent considerably decreases the reactivity toward
organolithiums.
R2
R1
R1
CHO
CN
R2Li, THF, –78 ˚C (to 0 ˚C for 1c)
O
NH
1a R1 = H
2
1b R1 = Cl
1c R1 = OMe
Scheme 1
Table 1. Preparation of 3H-isobenzofuran-1-ylidenamines (2)
Entry
1
R2 in R2Li
Ph
n-Bu
t-Bu
Ph
p-Tol
4-MeOC6H4
2 (Yield /%)a
2a (58)
1
2
3
4
5
6
1a (R1 = H)
1a
2b (42)
2c (36)
2d (56)
2e (52)
2f (42)
1a
1b (R1 = Cl)
1b
1c (R1 = OMe)
a Isolated yields.

HETEROCYCLES, Vol. 83, No. 1, 2011
101
It should be noted that the use of Grignard reagents, such as ethylmagnesium bromide and
phenylmagnesium bromide, in place of organolithiums proved to result in the formation of complex
mixtures of products, containing those probably arising from the addition of Grignard reagents to the
cyano carbon. The reaction of 2-benzoylbenzonitrile with phenyllithium gave a similar result.
2-Acetylbenzonitrile also did not work well due to deprotonation of !-hydrogen with organolithiums.
Compounds (1a) and (1b) were then allowed to react with lithium enolates of t-butyl acetate and
N,N-dimethylacetamide under the conditions as described above for the preparation of 3-substituted
3H-isobenzofuran-1-ylidenamines (2a-e) to give the corresponding 2-(3-imino-1,3-dihydroisobenzofuran-
1-yl)acetic acid derivatives (3a-c) in relatively good yields as shown in Scheme 2. The reaction of 1c with
lithium enolate of N,N-dimethylacetamide giving 3d also required raising the reaction temperature to 0 ˚C
and 2-cyano-4,5-methylenedioxybenzaldehyde did not give the desired product as well. It should be noted
that the stereochemistry of the imino moiety of each of the products 2 and 3 is not clear yet.
CH2COY
R1
CHO
CN
R1
MeCOY–LDA, THF, -78 ˚C (to 0 ˚C for 1c)
O
NH
1a R1 = H
3a R1 = H, Y = Ot-Bu 72%
3b R1 = H, Y = NMe2 67%
3c R1 = Cl, Y = NMe2 67%
3d R1 = OMe, Y = NMe2 56%
1b R1 = Cl
1c R1 = OMe
Scheme 2
R2
O
R1
aq. HCl, THF, rt or reflux
2, 3
O
4
Scheme 3
Table 2. Preparation of isobenzofuran-1(3H)-ones 4
Entry
2 or 3
2a
2e
2f
3c
3d
Temp
rt
rt
reflux
rt
reflux
Time
4 (Yield /%)a
4a (78)
4b (70)
4c (68)
4d (74)
4e (53)
1
2
3
4
5
overnight
overnight
4 h
overnight
4 h
a Isolated yields.

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HETEROCYCLES, Vol. 83, No. 1, 2011
Some of 3H-isobenzofuran-1-ylidenamine derivatives thus obtained were then hydrolyzed under acidic
conditions to give the corresponding phthalide derivatives. Thus, treatment of 2a, 2e, and 3c with 10 %
hydrochloric acid in THF at room temperature overnight gave the corresponding phthalide derivatives
(4a), (4b), and (4d), respectively, in relatively good yields (Entries 1, 2, and 4). Hydrolysis of compounds
2f and 3d, which have a methoxy group at the 5-position, under the same conditions proved difficult. The
higher temperature was required to accomplish hydrolysis of these compounds. Thus, heating solutions of
2f and 3d in THF containing 10 % hydrochloric acid at reflux temperature for 4 h provided the
corresponding phthalide derivatives (4c) and (4e), respectively, in moderate-to-fair yields (Entries 3 and
5).
In conclusion, we have demonstrated that 3-substituted 3H-isobenzofuran-1-ylidenamines can be
produced via addition of organolithiums or lithium enolates of t-butyl acetate and N,N-dimethylacetamide
to the carbonyl carbon of 2-cyanobenzaldehydes, followed, in the same pot, by intramolecular attack of
the resulting alkoxides on the cyano carbon. Acid treatment of some of these
3H-isobenzofuran-1-ylidenamines hydrolyzed the imino function to yield the corresponding
isobenzofuran-1(3H)-one derivatives. As the synthetic method reported in this paper starts with readily
available compounds and is operationally simple, it may find some value in organic synthesis.
EXPERIMENTAL
The melting points were obtained on a Laboratory Devices MEL-TEMP II melting apparatus and are
1
uncorrected. IR spectra were determined with a Shimadzu FTIR-8300 spectrophotometer. The H NMR
spectra were determined in CDCl3 using TMS as an internal reference with a JEOL ECP500 FT NMR
13
spectrometer operating at 500 MHz. The C NMR spectra were determined in CDCl3 using TMS as an
internal reference with a JEOL ECP500 FT NMR spectrometer operating at 125 MHz. Low- and
high-resolution MS spectra (EI, 70 eV) were measured by a JEOL JMS AX505 HA spectrometer. TLC
was carried out on a Merck Kieselgel 60 PF254. Column chromatography was performed using Merck
Kieselgel 60 (0.063–0.200 mm). All of the organic solvents used in this study were dried over appropriate
drying agents and distilled prior to use.
Starting Materials. 5-Chloro-2-cyanobenzaldehyde (1b)7,8 and 2-cyano-5-methoxybenzaldehyde (1c)7
were prepared by the appropriate reported procedure. All other chemicals used in this study were
commercially available.
Typical Procedure for the Preparation of 3-Substituted 3H-isobenzofuran-1-ylidenamines (2).
3-Phenyl-3H-isobenzofuran-1-ylidenamine (2a). To a stirred solution of 1a (0.14 g, 1.0 mmol) in THF
(2 mL) at –78 ˚C was added PhLi (1.08 M in cyclohexane; 1.0 mmol); the mixture was stirred for 15 min
at the same temperature before saturated aqueous NH4Cl (10 mL) was added in order to quench the
reaction. The organic materials were extracted with AcOEt three times (5 mL each), and the combined

HETEROCYCLES, Vol. 83, No. 1, 2011
103
extracts were washed with brine, dried over anhydrous Na2SO4, and concentrated by evaporation. The
residue was purified by column chromatography on silica gel (1:3 AcOEt–CHCl3) to give 2a (0.12 g,
58%); colorless needles; mp 121–123 ˚C (Et2O) (lit.,1 mp 120–121 ˚C); IR (KBr) 3298, 3284, 1686, 1614
cm–1; 1H NMR " 6.38 (s, 1H), 7.22 (d, J = 7.8 Hz, 1H), 7.26–7.28 (m, 3H), 7.34–7.40 (m, 3H), 7.50 (dd, J
13
= 7.8, 7.3 Hz, 1H), 7.54 (ddd, J = 7.8, 7.3, 1.4 Hz, 1H), 7.93 (d, J = 7.8 Hz, 1H); C NMR " 84.81,
122.46, 123.87, 126.96 (2C), 128.88 (2C), 128.95, 129.06, 132.31, 137.93, 147.17; MS m/z 209 (M+,
100).
3-Butyl-3H-isobenzofuran-1-ylidenamine (2b): a beige oil; Rf 0.29 (1:3 AcOEt–CHCl3); IR (neat) 3295,
1
3233, 1683, 1616 cm–1; H NMR " 0.92 (t, J = 7.3 Hz, 3H), 1.31–1.52 (m, 4H), 1.72–1.79 (m, 1H),
1.96–2.03 (m, 1H), 5.47 (dd, J = 7.8, 4.1 Hz, 1H), 7.26 (br, 1H), 7.26 (d, J = 7.8 Hz, 1H), 7.47 (dd, J =
7.8, 7.3 Hz, 1H), 7.56 (ddd, J = 7.8, 7.3, 1.4 Hz, 1H), 7.77 (d, J = 7.8 Hz, 1H); 13C NMR " 13.88, 22.49,
26.85, 34.94, 83.30, 121.35 (2C), 123.81, 128.59, 128.99, 131.92, 147.48; MS m/z 189 (M+, 100). Anal.
Calcd for C12H15NO: C, 76.16; H, 7.99; N, 7.40. Found: C, 76.06; H, 7.86; N, 7.48.
3-(1,1-Dimethylethyl)-3H-isobenzofuran-1-ylidenamine (2c): a pale-yellow oil; Rf 0.40 (1:1
AcOEt–CHCl3); IR (neat) 3296, 3219, 1683, 1615 cm–1; 1H NMR " 1.00 (s, 9H), 5.12 (s, 1H), 7.26 (br s,
1H), 7.44 (d, J = 7.3 Hz, 1H), 7.46 (t, J = 7.3 Hz, 1H), 7.52 (ddd, J = 7.8, 7.3, 1.4 Hz, 1H), 7.85 (d, J =
13
7.8 Hz, 1H); C NMR " 25.39, 36.00, 90.55, 123.01 (2C), 123.77, 128.58, 128.98, 131.43, 145.35; MS
m/z 189 (M+, 100). Anal. Calcd for C12H15NO: C, 76.16; H, 7.99; N, 7.40. Found: C, 75.87; H, 8.27; N,
7.67.
5-Chloro-3-phenyl-3H-isobenzofuran-1-ylidenamine (2d): a pale-yellow solid; mp 103–105 ˚C
1
(hexane); IR (KBr) 3277, 3230, 1676, 1605 cm–1; H NMR " 6.34 (s, 1H), 7.20 (d, J = 1.8 Hz, 1H),
7.25–7.27 (m, 3H), 7.39–7.41 (m, 3H), 7.46 (dd, J = 8.2, 1.8 Hz, 1H), 7.86 (d, J = 8.2 Hz, 1H); 13C NMR
" 84.25, 122.82, 125.18, 126.87 (2C), 129.05, 129.34, 129.70, 132.53, 137.23, 138.75, 148.85; MS m/z
243 (M+, 100). Anal. Calcd for C14H10ClNO: C, 69.00; H, 4.14; N, 5.75. Found: C, 68.98; H, 4.23; N,
5.68.
5-Chloro-3-(4-methylphenyl)-3H-isobenzofuran-1-ylidenamine (2e): a pale-yellow solid; mp 110–112
˚C (hexane–THF); IR (KBr) 3277, 1682, 1609 cm–1; 1H NMR " 2.36 (s, 3H), 6.30 (s, 1H), 7.13 (d, J = 7.8
Hz, 2H), 7.20 (d, J = 7.8 Hz, 2H), 7.29–7.33 (m, 2H), 7.45 (dd, J = 8.2, 1.8 Hz, 1H), 7.86 (br d, J = 8.2
Hz, 1H); 13C NMR " 21.20, 84.20, 122.78, 126.94 (2C), 129.68, 134.20, 135.71, 138.66, 139.39, 141.71,
142.99, 148.97; MS m/z 257 (M+, 100). Anal. Calcd for C15H12ClNO: C, 69.91; H, 4.69; N, 5.43. Found:
C, 69.91; H, 4.70; N, 5.26.
5-Methoxy-3-(4-methoxylphenyl)-3H-isobenzofuran-1-ylidenamine (2f): a colorless oil; Rf 0.28
(AcOEt); IR (neat) 3293, 1682, 1611 cm–1; 1H NMR " 3.80 (s, 3H), 3.81 (s, 3H), 6.27 (s, 1H), 6.62 (d, J =
2.3 Hz, 1H), 6.89 (d, J = 8.2 Hz, 2H), 7.01 (dd, J = 8.7, 2.3 Hz, 1H), 7.18 (d, J = 8.2 Hz, 2H), 7.26 (br s,
13
1H), 7.82 (d, J = 8.7 Hz, 1H); C NMR " 55.33, 55.66, 84.23, 106.47, 114.28, 116.28, 125.16, 125.62,

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HETEROCYCLES, Vol. 83, No. 1, 2011
128.76, 129.92, 130.89, 149.64, 160.27, 163.37; MS m/z 269 (M+, 100). Anal. Calcd for C16H15NO3: C,
71.36; H, 5.61; N, 5.20. Found: C, 71.22; H, 5.64; N, 5.19.
Typical Procedure for the Preparation of 2-(3-Imino-1,3-dihydroisobenzofuran-1-yl)acetic Acid
Derivatives (3). 1,1-Dimethylethyl 2-(3-Imino-1,3-dihydroisobenzofuran-1-yl)acetate (3a). To a
stirred solution of LDA (1.0 mmol), which was generated by the standard method, in THF (6 mL) at –78
˚C was added dropwise 1,1-dimethylethyl acetate (0.12 g, 1.0 mmol). After 15 min a solution of
2-cyanobenzaldehyde (1a) (0.14 g, 1.0 mmol) in THF (2 mL) was added and stirring was continued for an
additional 15 min before saturated aqueous NH4Cl (10 mL) was added. The organic materials were
extracted with AcOEt twice (10 mL each), and the combined extracts were washed with brine and dried
over anhydrous Na2SO4. Evaporation of the solvent gave a residue, which was purified by column
chromatography on silica gel to afford 3a (0.18 g, 72%) as a pale-yellow oil; Rf 0.32 (1:2 THF–hexane);
1
IR (neat) 3296, 1730, 1688 cm–1; H NMR " 1.45 (s, 9H), 2.78 (dd, J = 16.0, 6.4 Hz, 1H), 2.80 (dd, J =
16.0, 6.4 Hz, 1H), 5.82 (t, J = 6.4 Hz, 1H), 7.26 (br , 1H), 7.39 (d, J = 7.8 Hz, 1H), 7.49 (t, J = 7.3 Hz,
13
1H), 7.56 (ddd, J = 7.8, 7.3, 0.9 Hz, 1H), 7.86 (br d, J = 7.3 Hz, 1H); C NMR " 28.00, 41.33, 79.27,
81.69, 121.59, 123.94, 125.50, 129.04 (2C), 132.15, 146.29, 168.83; MS m/z 247 (M+, 1.2), 192 (15), 146
(100). Anal. Calcd for C14H17NO3: C, 68.00; H, 6.93; N, 5.66. Found: C, 67.95; H, 6.82; N, 5.64.
N,N-Dimethyl-2-(3-imino-1,3-dihydroisobenzofuran-1-yl)acetamide (3b): a pale-yellow oil; Rf 0.27
(1:6 MeOH–C6H6); IR (neat) 3256, 1682, 1643 cm–1; 1H NMR " 2.73 (dd, J = 16.0, 6.4 Hz, 1H), 2.99 (s,
3H), 3.00 (dd, J = 16.0, 6.8 Hz, 1H), 3.03 (s, 3H), 6.03 (dd, J = 6.8, 6.4 Hz, 1H), 7.26 (br, 1H), 7.47 (d, J
= 7.8 Hz, 1H), 7.50 (dd, J = 7.8, 7.3 Hz, 1H), 7.55 (td, J = 7.3, 0.9 Hz, 1H), 7.86 (br d, J = 7.3 Hz, 1H);
13C NMR " 35.46, 37.27, 39.41, 80.09, 122.34, 123.77 (2C), 128.29, 128.96, 132.18, 147.01, 168.91; MS
m/z 219 (M+1, 47), 218 (M+, 100). Anal. Calcd for C12H14N2O2: C, 66.04; H, 6.47; N, 12.84. Found: C,
66.06; H, 6.50; N, 12.80.
2-(6-Chloro-3-imino-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylacetamide (3c): a pale-yellow oil;
1
Rf 0.29 (1:6 MeOH–C6H6); IR (neat) 3258, 1688, 1643 cm–1; H NMR " 2.69 (dd, J = 16.0, 6.9 Hz, 1H),
2.99 (s, 3H), 3.01 (dd, J = 16.0, 6.9 Hz, 1H), 3.03 (s, 3H), 5.98 (t, J = 6.9 Hz, 1H), 7.26 (br, 1H), 7.45 (dd,
J = 8.2, 1.8 Hz, 1H), 7.55 (d, J = 1.8 Hz, 1H), 7.79 (br d, J = 8.2 Hz, 1H); MS m/z (%) 253 (M+1, 12),
252 (M+, 7.7), 180 (100). HR-MS Calcd for C12H13ClN2O2: M, 252.0666. Found: m/z 252.0651.
2-(3-Imino-6-methoxy-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylacetamide (3d): a colorless oil;
1
Rf 0.28 (1:6 MeOH–C6H6); IR (neat) 3284, 1682, 1640 cm–1; H NMR " 2.69 (dd, J = 16.0, 6.4 Hz, 1H),
2.98 (dd, J = 16.0, 7.3 Hz, 1H), 2.99 (s, 3H), 3.03 (s, 3H), 3.86 (s, 3H), 5.95 (dd, J = 7.3, 6.4 Hz, 1H),
13
6.98–7.01 (m, 2H), 7.36 (br, 1H), 7.74 (br d, J = 7.3 Hz, 1H); C NMR " 35.47, 37.31, 39.46, 55.70,
79.57, 99.90, 106.49, 116.24, 125.13, 128.31, 149.47, 163.26, 169.00; MS m/z 249 (M+1, 48), 248 (M+,
100). Anal. Calcd for C13H16N2O3: C, 62.89; H, 6.50; N, 11.28. Found: C, 62.87; H, 6.69; N, 11.29.
General Procedure for the Preparation of 3-Substituted Isobenzofuran-1(3H)-ones 4. A solution of 3

HETEROCYCLES, Vol. 83, No. 1, 2011
105
(0.5 mmol) in THF (3 mL) and 10% aqueous HCl (1.5 mL) was stirred for the time at the temperature
indicated in Table 2. The mixture was then treated with saturated aqueous NaHCO3 (10 mL) and the
organic materials were extracted with AcOEt three times (5 mL each). The combined extracts were
washed with brine, dried over anhydrous Na2SO4, concentrated by evaporation. The residual solid was
recrystallized to give pure 4.
3-Phenylisobenzofuran-1(3H)-one (4a): a white solid; mp 113–115˚C (CHCl3) (lit.,9 114–115 ˚C). The
spectral data for this product were identical to those reported previously.10
5-Chloro-3-(4-methylphenyl)isobenzofuran-1(3H)-one (4b): a pale-yellow solid; mp 164–166 ˚C
(CHCl3); IR (KBr) 1751 cm–1; 1H NMR " 2.37 (s, 3H), 6.33 (s, 1H), 7.14 (d, J = 7.8 Hz, 2H), 7.20 (d, J =
13
7.8 Hz, 2H), 7.30 (s, 1H), 7.52 (dd, J = 8.2, 1.8 Hz, 1H), 7.88 (d, J = 8.2 Hz, 1H); C NMR " 21.22,
82.15, 123.27, 124.19, 126.78, 126.94, 129.78, 130.11, 132.67, 139.67, 141.02, 151.44, 169.37; MS m/z
258 (M+, 100). Anal. Calcd for C15H11ClO2: C, 69.64; H, 4.29. Found: C, 69.48; H, 4.46.
5-Methoxy-3-(4-methoxyphenyl)isobenzofuran-1(3H)-one (4c):11 a pale-yellow solid; mp 99–101 ˚C
1
(hexane–CH2Cl2); IR (KBr) 1751, 1620, 1609 cm–1; H NMR " 3.82 (s, 3H), 3.88 (s, 3H), 6.63 (s, 1H),
6.94 (d, J = 1.8 Hz, 1H), 7.03 (d, J = 8.7 Hz, 2H), 7.22 (dd, J = 8.2, 1.8 Hz, 1H), 7.28 (d, J = 8.7 Hz, 2H),
7.88 (d, J = 8.2 Hz, 1H).
2-(6-Chloro-3-oxo-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylacetamide (4d): a pale-yellow solid;
mp 165–167 ˚C (CHCl3); IR (KBr) 1759, 1636 cm–1; 1H NMR " 2.68 (dd, J = 16.0, 8.2 Hz, 1H), 2.99 (s,
3H), 3.03 (s, 3H), 3.17 (dd, J = 16.0, 5.0 Hz, 1H), 6.00 (dd, 8.2, 5.0 Hz, 1H), 7.51 (dd, J = 8.2, 1.8 Hz,
1H), 7.73 (d, J = 1.8 Hz, 1H), 7.81 (d, J = 8.2 Hz, 1H);13C NMR " 35.44, 37.21, 38.63, 77.72, 124.07,
124.33, 126.67, 130.13, 133.01, 140.98, 151.57, 168.28; MS m/z 253 (M+, 100). Anal. Calcd for
C12H12ClNO3: C, 56.81; H, 4.77; N, 5.52. Found: C, 56.90; H, 4.80; N, 5.41.
2-(6-Methoxy-3-oxo-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylacetamide (4e): a pale-yellow
solid; mp 119–121˚C (hexane–CH2Cl2); IR (KBr) 1759, 1645 cm–1; 1H NMR " 2.68 (dd, J = 16.0, 7.8 Hz,
1H), 2.99 (s, 3H), 3.02 (s, 3H), 3.12 (dd, J = 16.0, 6.0 Hz, 1H), 3.89 (s, 3H), 5.95 (dd, J = 7.8, 6.0 Hz, 1H),
7.03 (dd, J = 8.7, 2.3 Hz, 1H), 7.12 (d, J = 2.3 Hz, 1H), 7.79 (d, J = 8.7 Hz, 1H); 13C NMR " 35.44, 37.32,
38.88, 55.83, 77.60, 106.98, 116.94, 117.98, 127.00, 152.78, 164.81, 168.70, 169.91. MS m/z 249 (M+,
100). Anal. Calcd for C13H15NO4: C, 62.64; H, 6.07; N, 5.62. Found: C, 62.63; H, 6.09; N, 5.52.
ACKNOWLEDGEMENT
We thank Mrs. Miyuki Tanmatsu of this university for determining mass spectra and performing
combustion analyses.
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