Potent, Low Molecular Weight Renin Inhibitors Containing a C-Terminal Heterocycle: Hydrogen Bonding at the Active Site

DOI: 10.1021/jm00168a009

Source and publish data:

Journal of Medicinal Chemistry p. 1582 - 1590 (1990)

Update date:2022-08-05

Topics:

Authors:

Rosenberg, Saul H.

Dellaria, Joseph F.

Kempf, Dale J.

Hutchins, Charles W.

Woods, Keith W.

et al. et al.

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Article abstract of DOI:10.1021/jm00168a009

A series of low-nanomolar renin inhibitors containing novel C-terminal heterocycles has been designed by formally cyclizing the C-terminus of a glycol-based inhibitor to the second hydroxyl.Molecular modeling suggests that the heterocyclic oxygen hydrogen

Full text of DOI:10.1021/jm00168a009

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