Tetrahedron Letters p. 1233 - 1236 (1998)
Update date:2022-08-04
Topics:
Pasto, Mireia
Moyano, Albert
Pericas, Miquel A.
Riera, Antoni
Highly enantioenriched cis and trans N-Boc-2,2-dimethyl-oxazolidine-5-carbaldehydes have been efficiently prepared from N-Boc-3-amino-1,2-alkanediols, readily available in enantiopure or enantioenriched form by Sharpless epoxidation methodology. These compounds have been converted into N-Boc-(S)-γ-[(S)-1-aminoalkyl]-γ-lactones which are key intermediates of hydroxyethylene dipeptide isosteres.
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