
Tetrahedron Letters p. 6711 - 6714 (1998)
Update date:2022-09-26
Topics: Ring closing metathesis Disubstituted
Sauriat-Dorizon, Helene
Guibe, Francois
Optically pure disubstituted dialkenic amides 2, which are direct precursors of Z-ethylenic pseudo-peptides 1, are readily synthesized and then cyclized to lactams 3 in the presence of Grubbs' ruthenium-based metathesis catalysts with total conservation of enantiomeric purity.
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