Enantioconservative synthesis and ring closing metathesis of disubstituted dialkenic amides

Article abstract of DOI:10.1016/S0040-4039(98)01432-4

Optically pure disubstituted dialkenic amides 2, which are direct precursors of Z-ethylenic pseudo-peptides 1, are readily synthesized and then cyclized to lactams 3 in the presence of Grubbs' ruthenium-based metathesis catalysts with total conservation of enantiomeric purity.