Discovery of AMG 853, a CRTH2 and DP dual antagonist

DOI: 10.1021/ml1002234

Source and publish data:

ACS Medicinal Chemistry Letters p. 326 - 330 (2011)

Update date:2022-07-29

Topics:

Authors:

Liu, Jiwen

Li, An-Rong

Wang, Yingcai

Johnson, Mike G.

Su, Yongli

Shen, Wang

Wang, Xuemei

Lively, Sarah

Brown, Matthew

Lai, Sujen

Gonzalez Lopez De Turiso, Felix

Xu, Qingge

Van Lengerich, Bettina

Schmitt, Mike

Fu, Zice

Sun, Ying

Lawlis, Shanna

Seitz, Lisa

Danao, Jay

Wait, Jill

Ye, Qiuping

Tang, Hua Lucy

Grillo, Mark

Collins, Tassie L.

Sullivan, Timothy J.

Medina, Julio C.

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Article abstract of DOI:10.1021/ml1002234

Prostaglandin D₂ (PGD₂) plays a key role in mediating allergic reactions seen in asthma, allergic rhinitis, and atopic dermatitis. PGD₂ exerts its activity through two G protein-coupled receptors (GPCRs), prostanoid D rece

Full text of DOI:10.1021/ml1002234

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