A mechanistic study of the FK-506 tricarbonyl system rearrangement: Synthesis of C.9 labeled FK-506

DOI: 10.1016/S0040-4039(01)93320-9

Source and publish data:

Tetrahedron Letters p. 6121 - 6124 (1989)

Update date:2022-09-26

Topics:

Authors:

Askin Askin

Reamer Reamer

Joe Joe

Volante Volante

Shinkai Shinkai

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Hydroxide mediated benzilic acid rearrangement of a C.9-¹³C labeled FK-506 derivative gave 97% rearrangement thru a C.8→C.10 acyl shift mechanism.

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