SINTHETIC STUDY ON VANCOMYCIN: SYNTHESIS OF MACROCYCLIC TETRAPEPTIDE AS A PLAUSIBLE ACTIVE CENTER IN VANCOMYCIN

DOI: 10.1016/S0040-4039(01)93850-X

Source and publish data:

Tetrahedron Letters p. 6043 - 6046 (1989)

Update date:2022-08-05

Topics: Stereochemistry Protecting groups Purification and characterization Peptide Synthesis Macrocyclization

Authors:

Suzuki, Yoshikazu

Nishiyama, Shigeru

Yamamura, Shosuke

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Article abstract of DOI:10.1016/S0040-4039(01)93850-X

Two macrocyclic peptides included in vancomycin have been synthesized using TTN oxidating method.Of them, the macrocyclic tetrapeptide is regarded as an important moiety of vancomycin which forms a binding pocket for the carboxylate region of the terminal D-Ala-D-alanine.

Full text of DOI:10.1016/S0040-4039(01)93850-X

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