Tetrahedron Letters p. 6043 - 6046 (1989)
Update date:2022-08-05
Topics: Stereochemistry Protecting groups Purification and characterization Peptide Synthesis Macrocyclization
Suzuki, Yoshikazu
Nishiyama, Shigeru
Yamamura, Shosuke
Two macrocyclic peptides included in vancomycin have been synthesized using TTN oxidating method.Of them, the macrocyclic tetrapeptide is regarded as an important moiety of vancomycin which forms a binding pocket for the carboxylate region of the terminal D-Ala-D-alanine.
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