Journal of Organometallic Chemistry p. C5 - C7 (1995)
Update date:2022-09-26
Topics:
Reetz, Manfred T.
Kindler, Alois
The conjugate addition of Grignard reagents RMgX to α,β-unsaturated ketones and esters is effectively catalyzed by soluble copper ate-complexes of the type CuX3Li2, e.g.CuI*2LiCl.In the presence of Me3SiCl the corresponding ketone enolsilanes are formed in high yield and selectivity.Diastereoselectivity in the case of chiral ketones is similar to that observed by using stoichiometric amounts of cuprates R2CuLi.Thus CuX3Li2-catalyzed 1,4-additions of Grignard reagents may be an industrially viable process.Keywords: Copper; Magnesium; Lithium; Silicon; Ketone; Enolsilanes
View Morewebsite:http://www.orchid-chem.com
Contact:+86-571-85395792
Address:607, North Zhongshan Road, Hangzhou 310000 China
Hubei Sky Lake Chemical Co., Ltd.
Contact:+86-27-87385545
Address:Te-2, Xijiao Chemical Park, Yuekou Town, Tianmen, Hubei, China.
Contact:86-516-66656369
Address:The west road of Huaihai, Xuzhou, China
Hangzhou Gangjin Chemical Co.,Ltd.(expird)
Contact:+86-571-85109780
Address:707 Zhejiang Minhang Bldg., No.290 Zhongshan North Road, Hangzhou 310003, China
Shanghai Micro-mega Industry Co., Ltd.
Contact:0086-21-34628682;57153848
Address:Rm413,No.413,West Meilong Road, Minhang District,Shanghai P R China
Doi:10.1021/jo00303a034
(1990)Doi:10.1016/S0040-4020(01)81379-X
(1990)Doi:10.1016/0022-328X(96)06268-7
(1996)Doi:10.1080/00397911003707188
(2011)Doi:10.1007/s13738-011-0028-5
(2012)Doi:10.1016/S0040-4039(01)93367-2
(1989)