Journal of Organometallic Chemistry p. C5 - C7 (1995)
Update date:2022-09-26
Topics:
Reetz, Manfred T.
Kindler, Alois
The conjugate addition of Grignard reagents RMgX to α,β-unsaturated ketones and esters is effectively catalyzed by soluble copper ate-complexes of the type CuX3Li2, e.g.CuI*2LiCl.In the presence of Me3SiCl the corresponding ketone enolsilanes are formed in high yield and selectivity.Diastereoselectivity in the case of chiral ketones is similar to that observed by using stoichiometric amounts of cuprates R2CuLi.Thus CuX3Li2-catalyzed 1,4-additions of Grignard reagents may be an industrially viable process.Keywords: Copper; Magnesium; Lithium; Silicon; Ketone; Enolsilanes
View MoreSuzhou Wedo Chemicals Co., Ltd.
Contact:86 512 58100425
Address:Zonger Road, DongSha Industry Park , Zhangjiagang, Jiangsu, China
Contact:13357117572
Address:No.149 Shiji dadao Road.
website:http://www.easchem.com
Contact:+86-731-89722861 89722891
Address:2/F-4/Bld Colorful Palace, No.605 Changsha Ave, Yuhua Area Changsha Hunan China.
Contact:0086-29-88315623
Address:S711, Innovation Bldg No.25 Gaoxin 1st Rd, Xian P.R of China 710075
Contact:86 311 85902108 / 85902109
Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China
Doi:10.1021/jo00303a034
(1990)Doi:10.1016/S0040-4020(01)81379-X
(1990)Doi:10.1016/0022-328X(96)06268-7
(1996)Doi:10.1080/00397911003707188
(2011)Doi:10.1007/s13738-011-0028-5
(2012)Doi:10.1016/S0040-4039(01)93367-2
(1989)
