A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates

DOI: 10.1039/c0ob00979b

Source and publish data:

Organic and Biomolecular Chemistry p. 1627 - 1631 (2011)

Update date:2022-08-05

Topics:

Authors:

Mossetti, Riccardo

Caprioglio, Diego

Colombano, Giampiero

Tron, Gian Cesare

Pirali, Tracey

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Article abstract of DOI:10.1039/c0ob00979b

α-Isocyanoacetamides, acyl chlorides and dialkylacetylenedicarboxylates undergo a smooth multicomponent reaction to produce dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates in good yield. The scope and mechanism of this new multicomponent transformation are

Full text of DOI:10.1039/c0ob00979b

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Product name:diethyl 2-(3-phenylpropanoyl)-5-[benzyl(methyl)amino]furan-3,4-dicarboxylate

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