A Novel Carbon-Carbon Bond-Forming Reaction of Triflates with Copper(I)-Catalyzed Grignard reagents. A New Concise and Enantiospecific Synthesis of (+)-exo-Brevicomin, (5R,6S)-(-)-6-Acetoxy-5-hexadecanolide, and L-Factor

Article abstract of DOI:10.1021/jo00301a038

We describe here a full accound of a highly concise and enantiospecific synthesis of (+)-exo-brevicomin (7), (5R,6S)-(-)-6-acetoxy-5-hexadecanolide (11), and L-factor (16) originating from D- or L-tartrates as chiral sources.The synthesis employs an effic