European Journal of Medicinal Chemistry p. 9 - 19 (1990)
Update date:2022-08-05
Topics:
Robert-Piessard, Sylvie
Le Baut, Guillaume
Courant, Jacqueline
Brion, Jean-Daniel
Sparfel, Louis
et al.
The inhibition of the carragenin-induced rat-paw edema by previously synthesized N-(4,6-dimethyl)-2-pyridinyl) benzamides was evaluated.Amoung the 29 tested compounds, secondary benzamides 1, 12 and tertiary benzamide 60 exhibited a significant anti-inflammatory activity.It prompted us to envision a pharmacomodulation in this series by structural modifications on the homocycle, the amide function and the heterocycle.Although benzamide 38, acetamide 50 and benzylamine 56 elicited marked inhibitory activity, none was more active than N-(4,6-dimethyl-2-pyridinyl) benzamide 1. The mechanism of the anti-inflammatory action of 1 was investigated.The results showed that this molecule reduced eicosanoid biosynthesis but was unable to reduce cyclooxygenase or lipoxygenase activities.Although it did not directly block phospholipase activity, however, an inhibitory process at this level is likely.
View MoreSuzhou Jingye Medicine & Chemical Co., Ltd
website:http://www.jingyechem.cn
Contact:+86-512-66658588
Address:No. 88, Sanlian Street, Jinfeng Road, Suzhou New District, Jiangsu Province, P. R. China
Xi'an caijing Opto-Electrical Science & Technology Co., LTD
Contact:+86-29-88294447
Address:NO.168 Zhangba Rd. East, Xi'an, P.R.China
website:http://www.afinechem.com
Contact:+86-571-85134551
Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China
Hangzhou Hysen Pharma co.,Ltd.
website:http://www.hysenpharma.cn/
Contact:0086-571-88298791
Address:#701,Gudun Road Hangzhou
Zibo Fuxi'er Chemical Co.,Ltd (Shanxian Fuxi'er Chemical Co.,Ltd)
Contact:+86-533-2091422
Address:Eastern 4 on the 3th Road ,Liangxiang Industrial Park, Zibo city ,Shandong,China
Doi:10.1007/BF00810293
(1990)Doi:10.1007/BF00506857
(1990)Doi:10.1002/hlca.19900730216
(1990)Doi:10.1021/jo01013a077
(1965)Doi:10.1021/ol200714h
(2011)Doi:10.1081/CAR-200040117
(2004)