European Journal of Medicinal Chemistry p. 9 - 19 (1990)
Update date:2022-08-05
Topics:
Robert-Piessard, Sylvie
Le Baut, Guillaume
Courant, Jacqueline
Brion, Jean-Daniel
Sparfel, Louis
et al.
The inhibition of the carragenin-induced rat-paw edema by previously synthesized N-(4,6-dimethyl)-2-pyridinyl) benzamides was evaluated.Amoung the 29 tested compounds, secondary benzamides 1, 12 and tertiary benzamide 60 exhibited a significant anti-inflammatory activity.It prompted us to envision a pharmacomodulation in this series by structural modifications on the homocycle, the amide function and the heterocycle.Although benzamide 38, acetamide 50 and benzylamine 56 elicited marked inhibitory activity, none was more active than N-(4,6-dimethyl-2-pyridinyl) benzamide 1. The mechanism of the anti-inflammatory action of 1 was investigated.The results showed that this molecule reduced eicosanoid biosynthesis but was unable to reduce cyclooxygenase or lipoxygenase activities.Although it did not directly block phospholipase activity, however, an inhibitory process at this level is likely.
View Morezhenjiang runjing high purity chemical co ltd
Contact:+86-511-83361155
Address:No.8.haixi road,international chemical park
suzhou BetterBioChem Co., Ltd.
website:http://www.betterbiochem.com
Contact:+86-18013506594
Address:No. 8 Building, 18 nong, Xi Yingnan Road, Pudong, Shanghai,China
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)
Contact:010-52876516
Address:tongzhoubeiyuan
Skyrun Industrial Co.,Ltd(expird)
website:http://www.chinaskyrun.com
Contact:0086-576-84610586
Address:Chemical Development Zone
Contact:+86-0571-87550459
Address:ROOM1202,BUILDING 1,JINWAN SYB MANSION, NO583, JINQIAO STREET, ECNOMIC DEVELOPMENT ZONE, HANGZHOU,ZHEJIANG, CHINA.
Doi:10.1007/BF00810293
(1990)Doi:10.1007/BF00506857
(1990)Doi:10.1002/hlca.19900730216
(1990)Doi:10.1021/jo01013a077
(1965)Doi:10.1021/ol200714h
(2011)Doi:10.1081/CAR-200040117
(2004)