Synthesis p. 1465 - 1479 (1995)
Update date:2022-07-29
Topics: Deprotection Purification Glycosylation Reaction Sugar moiety
Wilson
Hager
El-Kattan
Liotta
Different approaches for the synthesis of nucleoside analogs (potential HIV inhibitors) are described. Starting from a suitably substituted furanose ring, it is demonstrated that a high facial stereocontrol of the glycosylation reaction can be effected. Different reaction conditions including Lewis acid promoted, S(N)2 displacement and some enzymatic methodologies for the stereoselective synthesis of these compounds are reviewed.
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