
Tetrahedron Letters p. 7069 - 7070 (1989)
Update date:2022-07-31
Topics:
El Abbassi
Djerrari
Essassi
Fifani
Reaction of o-phenylenediamine 1 with dehydracetic acid 2 in different alcohols leads to 2-alkoxycarbonylmethyl 4-methyl 1,5-benzodiazepines 3-7, to 4-acetyl methylene 1,5-benzodiazepin-2-one 8, and to benzimidazoles 9 and 10. This constitutes a novel and efficient synthesis of some benzodiazepine derivatives.
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