Hydride reagents for stereoselective reductive amination. An improved preparation of 3-endo-tropanamine

Article abstract of DOI:10.1016/0040-4039(96)00760-5

The reductive amination of substituted cyclohexanones with sodium triacyloxyborohydrides derived from NaBH₄ and various carboxylic acids provides highly diastereoselective conversions to protected axial amines. This method was applied to the stereoselective preparation of 3-endo-tropanamine.