Asymmetric Synthesis of Pipecolic Acid Derivatives Using the Aza-Diels-Alder Reaction

DOI: 10.1016/S0957-4166(00)80025-7

Source and publish data:

Tetrahedron Asymmetry p. 1263 - 1282 (1991)

Update date:2022-08-02

Topics: Characterization applications Workup and Isolation Scale-up Reaction Conditions Selection of Starting Materials Chiral Catalyst

Authors:

Bailey, Patrick D.

Brown, George R.

Korber, Fritjof

Reed, Amanda

Wilson, Robert D.

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Article abstract of DOI:10.1016/S0957-4166(00)80025-7

Imines of the type R-N=CHCO2Et can be coerced into undergoing a (4+2) cycloaddition with substituted dienes if the reaction is carried out in DMF in the presence of both water and acid; these reactions show extremely high regio- and diastereoselectivity.U

Full text of DOI:10.1016/S0957-4166(00)80025-7

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