Divergent stereoselectivity in the reduction of α,β-epoxy ketones using hydridosilicates

Article abstract of DOI:10.1016/0040-4039(94)02255-A

α,β-Epoxy ketones are reduced by trimethoxysilane in the presence of a catalytic amount of lithium melboxide to yield the corresponding alcohols. This reaction system reveals divergent selectivity depending on the solvent; both anti-selectivity and syn-se