Synthesis and N- and C-terminal extension of peptidyl α, α-difluoroalkyl ketones

Article abstract of DOI:10.1016/S0040-4039(00)77704-5

A synthesis of the dipeptidyl and tetrapeptidyl α-α-difluoroalkyl ketones is described. The key intermediate 6 can be extended at not only the C-terminal but also the N-terminal.