Journal of Medicinal Chemistry p. 978 - 982 (1976)
Update date:2022-09-26
Topics:
Markovac
LaMontagne
Nine di and trisubstituted 9 phenanthrenemethanols bearing methylthio and methylsulfonyl substituents in the 2 and/or 6 positions of the phenanthrene nucleus were prepared and screened for antimalarial activity against Plasmodium berghei in mice. Six of the nine compounds were curative at or below 160 mg/kg. The most active structures contained a methylthio substituent in combination with two chlorine atoms.
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