Resolution of a CBI precursor and incorporation into the synthesis of (+)-CBI, (+)-CBI-CDPI1, (+)-CBI-CDPI2: Enhanced functional analogs of (+)-CC-1065. A critical appraisal of a proposed relationship between electrophile reactivity,

Article abstract of DOI:10.1016/S0040-4039(00)94629-X

Details of the resolution of an immediate CBI precursor, (+)- and (-)-8, and its subsequent incorporation into (+)- and (-)-CBI-CDPI(n), optically-active enhanced functional analogs of (+)-CC-1065, are described. In marked contrast to a previously detaile