Journal of Medicinal Chemistry p. 2270 - 2275 (1990)
Update date:2022-08-02
Topics:
Culbertson, Townley P.
Sanchez, Joseph P.
Gambino, Laura
Sesnie, Josephine A.
A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspiro<4.4>nonane (4b), 1,7-diazaspiro<4.4>nonane (5a), or 2,8-diazaspiro<5.5>undecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues.Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.
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Doi:10.1016/S0040-4039(00)70712-X
(1989)Doi:10.1021/jm00170a028
(1990)Doi:10.1039/c39900000526
(1990)Doi:10.1002/ejic.201001251
(2011)Doi:10.1016/S0040-4039(00)88917-0
(1990)Doi:10.1016/0223-5234(89)90027-5
(1989)
