Inhibition of human leukocyte elastase by C-2 substituted cephalosporin sulfones

Article abstract of DOI:10.1016/0223-5234(89)90027-5

Cephalosporin sulfones with a number of substituents at the C-2 position were prepared and tested as inhibitors of human leukocyte elastase (HLE), an enzyme implicated in the tissue destruction associated with pulmonary emphysema. Nearly all substituents