An efficient synthesis of methyl N-[2-(R)-(1-naphthylmethyl)-3-(morpholinocarbonyl)propionyl]-(S)- histidinate, the key synthetic intermediate of renin inhibitors

Article abstract of DOI:10.1016/S0040-4039(00)94685-9

Optically pure (R)-(1-naphthylmethyl)succinic acid could be efficiently prepared by a combination of optical resolution and racemization of the undesired enantiomer or by catalytic asymmetric reduction of (1-naphthylmethylene)succinic acid over a rhodium