Intrinsic pKa values of 3′-N-α-l-aminoacyl-3′- aminodeoxyadenosines determined by pH dependent 1H NMR in H 2O

Article abstract of DOI:10.1039/c0cc05136e

3′-(α-l-Aminoacylamido)deoxyadenosines are ribosomal A-site binders and mimic the nascent peptide accepting 3′-terminus of aminoacyl transfer RNA. Their α-amino groups exhibit intrinsic basicities in bulk water that differ by up to 1.8 pK_a unit