Bulletin of the Chemical Society of Japan p. 640 - 642 (1990)
Update date:2022-08-03
Topics:
Hiyama
Wakasa
Ueda
Kusumoto
A facile and practical method for the synthesis of 2-(6-methoxy-2-naphthyl)propenoic acid, a precursor of anti-inflammatory agent naproxen, is described. The method involves (1) Pd-catalyzed ethynylation of 2-bromo-6-methoxynaphthalene, (2) regioselective addition of HX to the triple bond, and (3) Pd-catalyzed carbonylation of the resulting vinyl halide followed by (4) alkaline hydrolysis.
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Doi:10.1007/s11172-015-1148-3
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