Quantitative Structure-Activity Relationship Analysis of Cation-Substituted Polyaromatic Compounds as Potentiators (Amplifiers) of Bleomycin-Mediated Degradation of DNA

DOI: 10.1021/jm00106a017

Source and publish data:

Journal of Medicinal Chemistry p. 580 - 588 (1991)

Update date:2022-08-02

Topics:

Authors:

Strekowski, Lucjan

Wilson, W. David

Mokrosz, Jerzy L.

Mokrosz, Maria J.

Harden, Donald B.

et al. et al.

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Article abstract of DOI:10.1021/jm00106a017

A set of 21 polyheteroaromatic compounds substituted with flexible cationic groups and of similar molecular size has been analyzed for binding with DNA and for effects on the bleomycin-mediated degradation of the DNA double helix.Increases in apparent rat

Full text of DOI:10.1021/jm00106a017

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