Syntheis and Antitumor Activity of Novel Mitomycin Derivatives Containing Functional Groups at the C-6-Methyl Position

DOI: 10.1021/jm00038a008

Source and publish data:

Journal of Medicinal Chemistry p. 1794 - 1804 (1994)

Update date:2022-08-05

Topics: Synthesis NMR spectroscopy Derivatives Cell Culture Chemical Synthesis In Vivo Testing Reaction Conditions Antitumor Activity Functional Groups

Authors:

Arai, Hitoshi

Kanda, Yutaka

Ashizawa, Tadashi

Morimoto, Makoto

Gomi, Katsushige

et al. et al.

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Article abstract of DOI:10.1021/jm00038a008

A series of C-6-substituted methyl mitomycins was synthesized and evaluated for anticellular and antitumor activities.These novel compounds were prepared by Michael addition of various alcohols or thiols to 6- demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-me

Full text of DOI:10.1021/jm00038a008

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