Journal of Medicinal Chemistry p. 1794 - 1804 (1994)
Update date:2022-08-05
Topics: Synthesis NMR spectroscopy Derivatives Cell Culture Chemical Synthesis In Vivo Testing Reaction Conditions Antitumor Activity Functional Groups
Arai, Hitoshi
Kanda, Yutaka
Ashizawa, Tadashi
Morimoto, Makoto
Gomi, Katsushige
et al.
A series of C-6-substituted methyl mitomycins was synthesized and evaluated for anticellular and antitumor activities.These novel compounds were prepared by Michael addition of various alcohols or thiols to 6- demethyl-7,7-(ethylenedioxy)-6,7-dihydro-6-me
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