Highly Diastereoselective 1,2-Asymmetric Addition of Dialkylzincs to Chiral 2-Phenylpropanal Catalyzed by Amino Alcohol

DOI: 10.1246/bcsj.63.2129

Source and publish data:

Bulletin of the Chemical Society of Japan p. 2129 - 2130 (1990)

Update date:2022-08-05

Topics: Chiral Diastereoselective Amino alcohol Asymmetric addition Dialkylzincs

Authors:

Soai, Kenso

Niwa, Seiji

Hatanaka, Toshihiro

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Article abstract of DOI:10.1246/bcsj.63.2129

Diastereoselective addition of dialkylzinc reagents to 2-phenylpropanal using amino alcohol as catalyst afforded erythro alcohols (Cram-selectivity) in high diastereomeric excess (up to 88percent d.e.).

Full text of DOI:10.1246/bcsj.63.2129

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