Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

DOI: 10.1021/jm101459g

Source and publish data:

Journal of Medicinal Chemistry p. 3206 - 3221 (2011)

Update date:2022-08-05

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Authors:

Bang-Andersen, Benny

Ruhland, Thomas

J?rgensen, Morten

Smith, Garrick

Frederiksen, Kristen

Jensen, Klaus Gjervig

Zhong, Huailing

Nielsen, S?ren M?ller

Hogg, Sandra

M?rk, Arne

Stensb?l, Tine Bryan

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Article abstract of DOI:10.1021/jm101459g

Figure Presented. The synthesis and structure-activity relationship of a novel series of compounds with combined effects on 5-HT_3A and 5-HT_1A receptors and on the serotonin (5-HT) transporter (SERT) are described. Compound 5m (Lu AA2

Full text of DOI:10.1021/jm101459g

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