Development of an 'Overmethylation' Strategy for Corrin Synthesis. Multi-enzyme Preparation of Pyrrocorphins

DOI: 10.1039/c39900000593

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Journal of the Chemical Society. Chemical communications p. 593 - 597 (1990)

Update date:2022-08-05

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Authors:

Scott, A. Ian

Warren, Martin J.

Roessner, Charles A.

Stolowich, Neal J.

Santander, Patricio J.

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Article abstract of DOI:10.1039/c39900000593

A novel trimethyl pyrrocorphin has been synthesized from 5-aminolevulinic acid (ALA) by the combination of the enzymes ALA dehydratase, porphobilinogen deaminase, uro'gen III synthase, and uro'gen III methylase, leading to a new concept for the synthesis of intermediates of vitamin B₁₂ biosynthesis.

Full text of DOI:10.1039/c39900000593

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