Synthesis and chemical reactivity of C-5 substituted 6,7-bis-(hydroxymethyl)-1H-pyrrolizine biscarbamate tumor inhibitors [1]

Article abstract of DOI:10.1002/jhet.5570270440

A series of C-5 substituted pyrrolizine biscarbamate alkylating agents were synthesized and evaluated in an in vitro alkylation assay. Introduction of electron-withdrawing substituents at the C-5 position resulted in a dramatic decrease in chemical reactivity toward the model nucleophile 4-(4-nitrobenzyl)pyridine (NBP).