Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazol e

DOI: 10.1021/jm00173a017

Source and publish data:

Journal of Medicinal Chemistry p. 3020 - 3023 (1990)

Update date:2022-08-04

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Authors:

Rosen Rosen

Seeger Seeger

McLean McLean

Nagel Nagel

Ives Ives

Guarino Guarino

Bryce Bryce

Furman Furman

Roth Roth

Chalabi Chalabi

Windels Windels

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Article abstract of DOI:10.1021/jm00173a017

4-(2-Methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole (5) is a highly potent member of a structurally novel series of selective serotonin-3 receptor antagonists. The synthesis of tritriated 5 and its binding profile in neuroblastoma-glioma 108

Full text of DOI:10.1021/jm00173a017

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