Chemical and Pharmaceutical Bulletin p. 2432 - 2441 (1992)
Update date:2022-08-03
Topics:
Katsura
Inoue
Tomishi
Itoh
Ishikawa
Takasugi
A series of 4-furyl-2-guanidinothiazole derivatives and related compounds were synthesized and evaluated for histamine H2-receptor antagonist and gastric acid antisecretory activities. Among them, compounds I-17, I-48 and I-49 showed high activities in these tests. In addition, compound I-17 possessed potent inhibitory activities on each of the gastric ulcers induced by stress, ethanol and HCl-aspirin. On the other hand, compound I-48 demonstrated antimicrobial activity against Helicobacter pylori and the potency was far stronger than that of clinically used H2-antagonists. Some structure-activity relationships are discussed.
View MoreQingdao XinYongAn Chemicals Co., Ltd
Contact:+86-532-81107967
Address:Chengyang dual-port industrial park by the sea，Qingdao
Taizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
website:http://www.acrospharmatech.com
Contact:+1-3234804688
Address:Flat/RM 1502,Easey Commercial building 253-261 Hennessy Road,Wanchai，HongKong
Wuxi D-Stone International Co., Ltd.
Contact:+86-510-82740567
Address:21F Hengtong Int'l Centre, 215Zhongshan Road, Wuxi, Jiangsu,China
Contact:+86-13666670345
Address:Agricultural Development Zone, Haining, Jiaxing, Zhejiang
Doi:10.1134/S0036023610070119
(2010)Doi:10.1002/aoc.1756
(2011)Doi:10.1016/j.ejmech.2011.02.002
(2011)Doi:10.1039/c0ob00680g
(2011)Doi:10.1007/BF00532087
(1992)Doi:10.1016/j.jorganchem.2010.12.033
(2011)
