Studies on antiulcer drugs. VI. 4-Furyl-2-guanidinothiazoles and related compounds as potent histamine H2-receptor antagonists

DOI: 10.1248/cpb.40.2432

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2432 - 2441 (1992)

Update date:2022-08-03

Topics:

Authors:

Katsura Katsura

Inoue Inoue

Tomishi Tomishi

Itoh Itoh

Ishikawa

Takasugi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.40.2432

A series of 4-furyl-2-guanidinothiazole derivatives and related compounds were synthesized and evaluated for histamine H₂-receptor antagonist and gastric acid antisecretory activities. Among them, compounds I-17, I-48 and I-49 showed high activities in these tests. In addition, compound I-17 possessed potent inhibitory activities on each of the gastric ulcers induced by stress, ethanol and HCl-aspirin. On the other hand, compound I-48 demonstrated antimicrobial activity against Helicobacter pylori and the potency was far stronger than that of clinically used H₂-antagonists. Some structure-activity relationships are discussed.

Full text of DOI:10.1248/cpb.40.2432

NII-Electronic Library Service

Products guided by the article

Product name:2-Furanacetonitrile, 5-(chloroacetyl)- (9CI)

Cas No:129596-27-6

R&D Labs maybe for 129596-27-6

Changzhou Kingyo Chemical Corporation Ltd.

website:http://www.kingyochem.com

Contact:+86-519-85105717

Address:19# Wuqing North Road, Changzhou , Jiangsu, China
Shanghai PuYi Chem-Tech Co.,Ltd.

Contact:+86-21-57687505-227

Address:3 Floor, Building 11, No 201 MinYi Road, Songjiang District, Shanghai 201612, China
Hangzhou LINGEBA Technology Co., Ltd.

Contact:+0086-571-87389059

Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China
Tianjin Ji Ping Jia Chemical Co., Ltd.

Contact:18622448868

Address:tianjin
Qingdao XinYongAn Chemicals Co., Ltd

Contact:+86-532-81107967

Address:Chengyang dual-port industrial park by the sea，Qingdao

Relevant to this article

Synthesis and molecular structures of the Co₃(μ-OOCPh) ₄(μ,η²-OOCPh)²[OC(Ph)OHNEt ³]² and Co(Hdmpz)₂(OOCPh)₂ complexes (Hdmpz = 3,5-dimethylpyrazole)

Doi:10.1134/S0036023610070119
(2010)
The synthesis of non-symmetrical stilbene analogs of trans-resveratrol using the same Pd catalyst in a sequential double-Heck arylation of ethylene

Doi:10.1002/aoc.1756
(2011)
Discovery of novel SCD1 inhibitors: 5-Alkyl-4,5-dihydro-3H-spiro[1,5- benzoxazepine-2,4′-piperidine] analogs

Doi:10.1016/j.ejmech.2011.02.002
(2011)
Sugar-bearing tetraphenylethylene: Novel fluorescent probe for studies of carbohydrate-protein interaction based on aggregation-induced emission

Doi:10.1039/c0ob00680g
(2011)
NITROAZINES. 18. ARYLATION AND DESTRUCTION OF 6-NITRO-1,2,4-TRIAZOLO<1,5-a>PYRIMIDINES

Doi:10.1007/BF00532087
(1992)
Synthesis of dineophyltin dihydride and stereoselective hydrostannation of alkynes and (E)-trisubstituted alkenes

Doi:10.1016/j.jorganchem.2010.12.033
(2011)

Article Doi