Simple and efficient synthesis of 2,6-dialkyl-3,5-dialkoxycarbonyl-4-(3- aryl-1-phenyl-pyrazol-4-yl)pyridines using TPAP/NMO as a catalyst under mild conditions

Article abstract of DOI:10.1016/j.tet.2011.02.040

Biologically important pyrazolylpyridines were synthesized in excellent yield by the oxidation of pyrazolyl 1,4-dihydropyridines (pyrazolyl 1,4-DHPs) using tetrapropylammonium perruthenate/N-methylmorpholine-N-oxide (TPAP/NMO) under mild conditions at 0 °C.